Tyrone

We live in an age where everything that can be automated has either already undergone automation or is semiautomatic. Some things that had no business being automated are also automatic. We walk less, we run even lesser, our diets are a mess, and nearly everyone is overweight. Two generations ago people ate more non-organic foods, smoked and drank more and yet they were far healthier than most of us.

According to some studies that were conducted recently, it was found that 60% of Americans are not doing the minimum daily exercise needed. Furthermore, the study discovered that out of this population, over 25% were such that their physical movements were almost negligible. However, since our lifestyles have grown to be such that our paychecks come from sitting in an office chair all day, most people need some sort of alternative that does not ask them to spend 9 hours a week in the gym.

This is the reason for the recent popularity of Pilates exercises. These exercises are simple so that anyone, in any physical condition, and of any age can perform them without the need of fancy equipment or lots of spare time.

Just as you would wear different apparel when going to weight training or an aerobics class, you should also pay attention to what you wear during Pilates exercises. Make sure that whatever you wear is comfortable even if it is not fashionable. Pilates exercises can ask you to twist and contort your body into some awkward positions initially and the last you want is to be discomfited by your clothes.

Wear clothes that hug your body. As with all exercises, the clothes you wear during a pilates workout should permit easy breathing and movement and should not be susceptible to flapping around. Also make certain that the clothes do not weigh too much. Some track pants material can be downright heavy. The lighter your Pilates exercise costume the better it will be for you. Pilates involves a lot of stretching and bending. At times like these and during certain postures, the obvious clothing items like extra buttons, zippers, beads can become a pain when they intrude between folding muscle layers so avoid those and wear plain clothing.

Check out http://www.pilates-class.com for more info.

You can find more great Pilates information at http://www.pilates-class.com Check out some of the comments by top pilates instructors.

Animals continue to be extensively used as research specimen in almost every major medical breakthrough. Utility of animals in medical research has been widely acknowledged. A wide variety of animal species are used for research that range from fruit flies to non-human primates. Research using non-human primates is required for testing drugs, clinical trials, neurology studies, evolution, genetics, behavioral aspects, reproductive biology, cognitive science and even in Xenotransplantation. An estimated 65,000 non-human primates are used annually for research purpose in UK and USA alone.

Use of non-human primates is significant as their brains share structural and functional similarity with the human brain. Most commonly used non-human primates for research purpose include apes, gorilla, chimpanzee, macaques, marmosets, baboons and orangutans. However, the use of non-human primates has always been controversial as it is related with ethical issues.

As per the United Nations Universal Declaration of Human Rights, human interests are protected by the law as they are considered legal persons. Non-human primates do not enjoy any such privilege. However, this status has always been a continuous topic of debate. Considering research on primates as unethical, various countries including Australia, Sweden, New Zealand and Netherlands have prohibited doing any kind of experimental using great apes, a biological family that comprises of gorillas, chimpanzees, bonobos, orangutans and humans. Considering the fact that animals do have a similar sense of pain and trauma as like humans, several organizations, animal rights groups, philanthropists, animal lovers, researchers, philosophers and primatologists are advocating for a world wide prohibition over the use of primates in research.

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'When is the best time to get pregnant?' is a question that our web site visitors ask again and again. The answer is simple, at the time of ovulation. Becoming pregnant however isn't simply a matter of depositing sperm in the woman at or around ovulation time. For the sperm and the egg to be fertile and for the male sperm count to be high a certain care of ones body and mind is needed. Basic care such as healthy eating, * definitely no smoking, no drinking, no drug taking (including prescription drugs if at all possible - consult your doctor), combine this with a generally stress free life and your chances of conception will increase greatly.

*Smoking not only fatally damages the unborn child but also greatly reduces the risks of conception.

To further increase your chances you should be aware that excessive ejaculation greatly reduces the sperm count and therefore also reduces the chances of fertilization. Making love twice a day every day to ensure that at the unknown moment of ovulation there is sperm present is NOT the answer to getting pregnant. The woman's cycle should be plotted as best as possible and the couple should learn the tell tale signs of ovulation so as to know exactly when ovulation is about to occur. There are many ways of 'getting to know' your cycle and body that are outlined in other articles which can be found at http://pregnantfocus.com

Once the couple is aware of the approximate ovulation time, make love once every 2 or 3 days, keep healthy bodies and healthy states of mind and then conception should occur without problems in the majority of couples.

Gabby Ford writes for the Pregnant Focus web site at http://pregnantfocus.com

Much of the business force in the United States is self-employed. Despite this fact, lenders have a bear of a time coming up with ways to handle such people.

Home loan lenders like things in a nice, orderly box. They dont like variations. They want certain numbers to appear on their applications. They then want to take these numbers and run them through their nice computer program, which then kicks out a yes or no answer on whether the loan should be made. Self-employed borrowers do not fit within this nice, neat box scenario.

Some fabulously successful self-employed people have major problems getting home loans. How can this be? Well, the problem is they do not look so successful on their tax returns. This is due to the fact there is an inherent conflict involved between ones tax return and ones mortgage application.

As we all know, the goal with taxes is to reduce our taxable income. For the self-employed person, this involves deducting everything including the kitchen sink. Obviously, the deductions need to be and should be legal. The goal, however, is to show as little taxable income at the end of the painful process of filling out ones tax return. This sounds great, but leads to a problem when applying for a loan.

One of the biggest factors in borrowing money for real estate is your income. Specifically, how much do you make in relation to what you want to borrow? Well, most lenders will check your tax return to make the determination. Now you see the problem. The income you minimized for tax purposes kills your prospects for getting a loan! It is the veritable catch-22.

So, do you have any options for getting around this? There are a couple of approaches. The first is to get the lender to eliminate paper deductions when calculating your income. You can deduct certain things that dont really come out of your pocket, such as depreciation. If the lender will set aside these deductions, your income will look better.

The second approach is to put more down on the purchase. If you can get to a point where you are putting 25 to 30 percent down, a lender will often disregard your income issues. Why? Well, you must have income or you wouldnt be able to come up with the hefty down payment!

Being self-employed is great until it comes time to apply for a loan. Then, it can be a real bear. Try to work creatively with your lender to find a solution that works for both of you.

Read more real estate articles for free at FSBOAmerica.org

Getting organized at home can be challenging especially for homes that have one parent households or both parents work, or where the family's schedule is constantly go and go some more. For most people, having an organized home is a continuous test of patience and determination.

Do you have a specific place, more then one spot, or an entire room in your home that desperately needs a clean sweep? Have you ignored those spots so long that the dirty sites are nagging you in the back of your mind? Don't grit your teeth and sigh; we have all been there at one point or another. There are easy solutions to your problem areas, let's do a clean sweep!

The guideline questions for clean sweeping your dirty room are; when did I last use this? When did I last wear this? When did I last play with this toy? What condition is the item in question found? The general answers to these questions are, if item is in bad condition throw it out. If you used the item the last time more then 18 months ago, donate it to charity or your garage sale. Toys can be tricky, are they memorable because they have meaning or are you a packrat?

Your ability to clean sweep the room depends on your willingness to be honest with yourself, but you say, it's a shame to throw out good stuff. If your "stuff" in question is in good condition, ask yourself, do you really want to keep this? If no, then you need to do some research on where to sell the items or where to donate it.

A problem a lot of households face is the paper issues, we generate a lot of paper, what to do with it all? Let's break down our paper mess. You need to divide your paper into several piles. Pile one, should be all the paper that has your personal information with on it, such as social security numbers, bank account numbers, credit card numbers. The second pile should be for each person in your household, and the third pile is for the trash. Anything that does not belong to one of your family members or have personal information on them needs to be placed in a trash bag and put to the curb.

Now, let's clean sweep the two piles that we have left. The pile that belongs to family members needs to be placed on the dining room table and when they gather for the evening meal, you need to ask them, to sort through it and throw out what they don't want and then they need to place it neatly in their rooms.

The last pile needs to be separated further, the first pile needs to be items that have nothing to do with paying your taxes, and the other is the paper pile that you will need to take to your tax accountant.

The pile that has nothing to do with taxes, you need to shred. Remember that trash is public domain and identity thieves like to go dumpster diving. Shred the papers that you don't need to take to your tax accountant and put the shredded paper to the curb.

The pile of papers that you need to take to your accountant needs to be placed in a file folder; ideally, you should have 12 folders. (They should have ends that are enclosed.) One folder for each month of the year, place the receipts dated in that month in the matching folder. Place your folders in a special spot, so the next time you have a tax receipt it can go straight into the proper folder.

Now, you're saying, but the spot that's a mess and needs a clean sweep is not paper, what do I do now? What are the items? If they are decorations for a holiday, purchase plastic containers that you can stack and place them inside, a closet under the short clothes, if your closet has shelves place these containers on the shelves. If your bed is high off the floor and depending on the shape of your container, you can slip the boxes underneath your bed.

Are you saying you don't have time for a clean sweep? Well, clean sweep one spot each night when you get home, five work nights equals five spots are clean swept each week, seven spots if you do one spot on each weekend day. Eventually all those untidy areas of your home will turn into clean rooms and lend a sparkling feeling to your dwelling.

Last, but not least helpful organization tips for that room that is entirely a disaster. First, enlist the help of your entire family. Advise them of what you are planning to do and agree on a weekend day that everyone can pitch in for a clean sweep of the room.

Now you have helpers. On the day, you have chosen for your clean sweep, have all the stuff taken out of the room. Divide the items up into three piles, keep, maybe keep, and toss out. After removing the items from the room, get trash bags out and dispose of all the stuff in the toss out pile.

Now apply the questions that we discussed above to the two remaining piles and divide both piles again into charity, garage sale, and keep. After this, take the stuff to the car that is going to be donated to charity and take it immediately to that charity.

If you have items to sell, keep them in the garage and the next sunny day, drag them to your yard and sell what you can, however, if you don't sell all the stuff, the rest of the garage sale items need to be taken to a charity.

Now all you should have left is the pile of belongings that you want to keep. Now evaluate your room. What are you going to use this room before it became chronically disorganized?

Now make it into that room. If you need shelving, buy it, if you need new paint get it, if you have a closet and have no intention on using the closet for clothing, use it for storage and put shelving into it. Old dressers are wonderful for storage if you are short on funds.

Regardless of which room or rooms in your home that requires a clean sweep, the guideline questions remain the same. When did I use this last? What condition is it in? Why am I keeping this item? If you cannot give a good answer to two of these questions, then you really need to dispose of the property in question.

When you move into the final phase of your clean sweep, you need to visualize the way you see the room when you are all done with the clean sweep and work towards those goals. There many ways to reach your final goal, sometimes it might be easier to go the store where they sell organization goods and price what you have in mind and then ask if there is a cheaper way to accomplish your final goals.

When you final touches are made to the clean room, show it off to your family and friends. To keep a real fund record of your clean sweep, take before and after pictures.

Another ideal way to optimize a clean sweep is as you are packing to move to another residence. You apply the guideline questions, but a much grader scale, the key is to evaluate everything you pack with extreme prejudiced. After all, if you trash it, give it away, or sell it, you will have to pack and move it! The extra space you will have in your new home will astound and please you and make you proud of your clean sweep.

Now you have turned your chronic disorganization into a totally organized home. Congratulations on a successful clean sweep!

April Pitcher
http://www.info4newaffiliates.com

The HP iPAQ hw6915 is also known as HPs mobile messenger. The simple reason for this is the fact that there is almost no modern feature that you will not find in this device. In terms of its design, HP also did a great job of incorporating a keyboard into the hw6915, which is surprisingly comfortable to use. At first sight, this device looks pretty much like most of the other Pocket PCs available on the market (barring the keyboard, of course). Upon closer inspection, we were very surprised to find not only an integrated GPS receiver, but also a built-in GSM radio, 802.11b Wi-Fi, and Bluetooth. This, means that with the hw6915 you only have to carry one device with you, as it will replace your Pocket PC, cellphone and GPS receiver. Even though the technical specifications on this device are on par with other high-end Pocket PCs, its good to see that HP did not cut corners when it comes to device performance.

The Intel PXA27O processor runs at 416MHz, and there is 128MB of system ROM and 46MB of RAM. A feature HP introduced in earlier versions of its Pocket PC range is the flip-up screen protector. Although this is a very handy feature, it can sometimes get in the way. Fortunately, you can view your screen with the protector on. The only thing we could really find fault with was the lack of a car charger and cradle in the bundle. Because this device sports such an array of features the battery life is not spectacular, and being able to use the GPS in your car while it is charging would be the ideal scenario. Still, we feel that this is a great product and you will be hard pressed to find another Pocket PC to equal this ones performance and feature set.

GPS is even useful for cycling

Whether you are searching for a career in fashion modeling or glamour modeling, it is very important for you to realize that there is more to becoming a model than just standing there looking beautiful.

One very important factor in becoming a good model is posing, and in order for you to learn the different poses needed for the type of modeling career you are seeking it will take practice, practice, practice.

Make Your Posing Look Natural

When preparing for your photo shoot, there are numerous steps you can take to ensure you are comfortable while posing and your photos will look more natural.

Get Posing Ideas

Before you head to your photo shoot, pick at least ten poses you really like from fashion or glamour magazines, or poses youve learned from previous photo shoots. Take time to practice each pose in front of a mirror until you feel comfortable and have the confidence of knowing you look great doing these poses.

Hands and Facial Expression

Also, focus on what to do with your hands and pay attention to facial expressions. A pose is virtually dead and unimaginative without a look. You should be able to close your eyes, imagine a thought, open your eyes and sell that thought. Practice this technique and your photos will come alive.

Become an Idea Factory

Unless you are shooting for an advertising agency or some other type of special interest session many photographers recommend that you bring some of your own posing ideas to the shoot. In addition to your ideas, the photographer may have his or her own idea of how the session should go.

Rapport with Your Photographer

Always work with a photographer you feel you can trust. This will make communication between the two of you easier and give you the confidence to express your own ideas.

Always listen to what the photographer tells you. If you are really uncomfortable with the pose, let your photographer know how you feel, in a nice way. Remember, he is looking through the camera lens and might see something you dont.

If the photographer says she wants something different in the pose, try looking away from the camera or giving a unique facial expression. This is where your practice in front of the mirror really pays.

Posture

When posing you should always keep good posture unless the photographer instructs you to do otherwise. Hold your stomach in to give your abdomen a more toned appearance. If you have gained a few pounds stick out your chin a little to avoid the appearance of a double chin in your photos.

Keep your fingers slightly apart and pointed away from the lens. Let your hands fall naturally into position whenever possible. Remember, you want to be yourself on purpose.

Now that you have learned what to do, consider these things you should try to avoid while posing.

Things to Avoid when Posing for a Photographer

Misplaced Body Language

Body language and expressions come naturally but the language you are projecting might not be what your photographer wants in a particular pose. You need to conciously focus on ways to prevent these habits while posing.

Dont hold your breath during a pose. Stay relaxed and your photos will look as if you just happened to be sitting this way when the photographer walked up.

In most pose situations you want your arms, legs, wrists, etc. slightly bent unless you are directed to do otherwise Most people dont stand or sit with their arms and legs completely stiff. A good point to remember is, if it will bend, bend it.

Mona Lisa Smile?

Another posing tip to remember is that you dont always have to smile. You should have a good variety of smiling and serious looks. But, sometimes you will want to give a large, open-mouthed laugh. If you are susposed to be happy, look the part!

Your Eyes are the Windows to Your Soul

Dont always look straight into the camera. When you cut your eyes to the left or right, you create an air of mystery. When you look up and away, you are annoyed. Tilt your chin slightly down and look straight ahead for a sexy look.

About Blinking

Beware of the Blink! If you have to blink, try to blink between exposures. This is not always easy, especially if you are working in a photography studio. Some models get into a habit of anticipating the strobes and start to close their eyes when the picture is about to be snapped.

Get into the habit of not paying attention to the flash and concentrate wholy on the pose, your body language, hand position, etc. and your images will come out as you expect.

Be Bold!!

Never be afraid to try out some of your own poses in front of your photographer. Most photographers are glad to hear suggestions from you.

How do You See Yourself?

When you look at your final images dont be critical of yourself. Find positive ways to improve your posing. Discover your strengths and weaknesses and shoot for the stars.

I am certain that Tyra Banks still works on her appearance and her posing artistry even though she has achieved a degree of stardom. Shouldnt you?

Bob Pardue is a professional model and fashion photographer. You can get free modeling tips by going to http://www.bobpardue.com/newsletter/subscribe/

Male Pattern Baldness is a condition that will affect a large proportion of men at some point in their lives. It is a condition which has been around since ancient times, and some of the remedies include pigeon droppings, and electric shock treatment to the scalp. Nowadays, the hair loss prevention product market in the United States alone is said to be worth $1 Billion, and while none of the pharmaceutical giants are likely to try and peddle pigeon droppings as a cure, there are nonetheless some snake oil products on the market. This article will look at three of the more reputable hair loss prevention products available today.

Rogaine

Rogaine (or Regaine outside the US) is the brand name for Minoxidil, which actually was used as a treatment for high blood pressure. It was discovered by accident that this drug helped as a hair loss remedy, and is now branded as such. Minoxidil works by stimulating hair growth, however, it has no effect on receding hairlines, and it can take between 4 and 12 months for any benefits to start showing. Another factor to consider is that most new hair will be lost after only a few months of stopping taking Minoxidil. This drug is applied to the scalp, in liquid or foam form, twice a day.

Propecia

Propecia is one of the brand names for Finasteride, which like Minoxidil, was originally used as a treatment for a completely different condition in this case prostate enlargement. Basically, Finasteride works by suppressing the enzyme which converts testosterone into dihydrotestosterone (DHT), which is thought to be one of the causes of Male Pattern Baldness. It has not been proven that Propecia can remedy frontal hair loss, although by combating the production of DHT, the scalp thinning process can be slowed down.

Provillus

Provillus comes in pill form (2 per day) and works by suppressing the production of DHT and also providing hair growth stimulating nutrients. Provillus is an all natural supplement, so no prescription is needed. There dont seem to be any documented side effects either. Crucially, Provillus comes with a 100% money back guarantee, which indicates that the manufacturer has a lot of confidence in it. It would appear also that 3-6 months is the timeline for hair growth using this supplement, so it is important not to invoke the money back guarantee too soon

As you will be aware, there are a lot of remedies on the market for male pattern baldness, and while the world has moved on from the days of rubbing pigeon droppings into the scalp, there are still a lot of miracle cure peddlers. The three remedies discussed above are proven to be effective, and should definitely be investigated further by anyone seeking a hair loss prevention product.

If you found that article of interest, please visit http://www.provillus-facts.com to learn about one of the newer hair loss remedies on the market.

Run by AIG, the world's leading financial services and international insurance organization, Travel Guard Insurance is one of the few companies you can bank on for dependable travel insurance service.

Boasting real 24/7 customer service, Travel Guard Insurance makes use of its "World Service Center" to attend to emergency calls round the clock. For the travel insurance industry, this type of service is essential because one phone call may literally mean saving a life.

If you're still having second thoughts on whether to get travel insurance or not before embarking on your next trip, consider this: Let's say a huge blizzard forces you to cancel trip for a reason that's one of those stipulated in the policy. The airline offers to guarantee you a seat on the next plane that's cleared for travel, but the delay would render your trip useless.

This means that without travel insurance, something that's as unavoidable as inclement weather could mean money down the drain for you. If you've purchased non-refundable tickets, you won't be able to get a single cent out of the cancellation, and that's not counting the time, money, and effort wasted falling in line and arranging for your trip in the first place.

Travel Guard Insurance has more than 6 million travel insurance clients who now feel safe and secure after purchasing one or more of their different packages. It's important to carefully choose which package or plan is best for you, as not all plans are appropriate for all people.

One of Travel Guard Insurance's Plans, called the "All-Inclusive," is their basic plan that can cover anyone from age 0 to 69. Some of the benefits included in this package are: accidental death and dismemberment; trip delays, interruptions, or cancellations; 24/7 emergency medical assistance; damaged, delayed, or lost baggage; and emergency illnesses or accidents.

A policy that is unique to Travel Guard Insurance is their "Protect Assist" plan ideal for individuals who are traveling on a limited budget. It offers general protection at a reasonable price. Make sure that your Travel Guard Insurance representative explains to you all the features and limitations of this policy that you need to know.

For those who are traveling in a group, Travel Guard Insurance offers the "Travel America Plan" which covers a lot of important items relevant to traveling by air or by car. It provides for up to a year's worth of medical insurance after an illness, provided that the initial treatment was given during your insured trip.

To know the policy best suited for your needs, go online and search for client feedback on Travel Guard Insurance's services. It's always better to hear from an unbiased individual so you would be able to do an objective comparison shopping of policies. After all, you're putting good money into whatever type of travel insurance you'd eventually avail of.

You can also find more info on Travel Insurance For Backpackers and Travel Insurance Tips. travelinsurance-help.com is a comprehensive resource to get information about Travel Insurance.

My search for a possible cancer cure began in late 2004 when I found out that my cousin, lifelong friend and running buddy, Jeff Johnson, had been diagnosed as having stage-three melanoma. The cancer had appeared out of nowhere and so it was quite a shock to my cousin and everyone close to him. As luck would have it, I had spent a lot of time the previous four years or so working on my dream of someday posting a website aimed at helping aging baby boomers and others live longer, healthier and happier lives. Naturally, a lot of my research involved searching for ways to ward off and treat diseases and ills such as cancer, Alzheimers, heart disease, high blood pressure, kidney and liver disease, and so forth. When I found out about my cousin, I already had a head start on knowing where and how to look, and so I began to redouble my efforts and focus my research more on cancer. As a result of my research, I found a lot of very good information about fighting cancer and other diseases, boosting our immune systems and improving health in general - much of which you may find in my simple How to Live a Long and Healthy Life book. However, it was not my research that led me to finding out about the magical, miraculous oleander plant it was a card game!

Yes, the way I first heard about the healing powers of oleander happened one evening when I was sitting down at a friendly card game and mentioned my cousins cancer. An acquaintance of mine whom I had known for a few years and who had worked for the American Medical Association at one time, looked across the table at me and, as serious as could be, said I know a cure. He then proceeded to tell me an amazing story of what he knew about oleander. Later, I found others who told me essentially the same basic story, although each person seemed to have a slightly different version. I fully expect that the story is headed toward becoming a modern day legend someday. Although the versions I heard have differed somewhat, the basic story line I believe to be essentially correct is as follows:

In the early 1960's a Turkish doctor by the name of Huseyin Ziya Ozel was searching for a cure for his pet dogs cancer when he noticed that a large number of Turkish villagers referred to him came from high altitudes and he thought that perhaps there was more to the story than just the higher incidence of skin cancer associated with higher altitudes:

In many versions of the story, Doctor Ozel was reported to have observed Turkish villagers drinking an oleander remedy, which pretty much correlates with the description of Oleander Leaf on the American Cancer Society website, where it states that Doctor Ozel started his study of oleander because of folk traditions that suggested that an extract from oleander was active against leukemia. It should be noted that Doctor Ozels daughter Sumru disputes this version and states that Doctor Ozell studied folkloric remedies and discovered that poultices made of crushed oleander leaves and flour were applied topically to wounds and produced amazingly fast healing of the wounds. The author suspects that this version may have been put forward to put distance between what Ozel observed and what he later patented in order to protect the patent from challenges.

According to Ozels daughter, Doctor Ozel made an observation that the majority of cancer patients referring to him were coming from an altitude above 600 meters. He thought that there should be a correlation between the rate of cancer occurrence and some environmental influence.

Whatever the actual truth, Doctor Ozel obviously did observe Turkish villagers using oleander and did review that use as well as a number of environmental factors, and he proceeded to continue his research on oleander based on what he found.

Further research showed that Nerium Oleander was most abundant in lower altitudes and practically did not exist at high altitude. Satisfied that he may have determined the cause of the villagers good health, Doctor Ozel became intrigued with the plant and began to prepare and work with various extracts of Oleander himself in 1966 while he was the head of the surgical department at Mugla State Hospital of Turkey.

Doctor Ozel first conducted animal studies to determine that the substance was non-toxic and, once he determined the toxicology and effects of Nerium Oleander Extract (or NOE), he conducted further experiments and developed his treatment in various forms until he eventually started tests on terminal human cases.

After initial success in treating human cancer patients with NOE, Doctor Ozel began to discussing his findings with other professionals in his field. He sought analysis of the extract from various Turkish laboratories to understand the empirical results. They were unable to characterize the extracted compounds. In hope of gaining assistance from the government or research organizations, he prepared a paper to present his first human cases at the Fourth Balkanic Medical Days Symposium held in Ankara on 20 September 1973.

The cases presented were all considered terminal cases when the patients came to Doctor Ozel. By law, he could not treat patients with an experimental drug, such as NOE, unless they had exhausted all other conventional treatment methods with no response or were diagnosed as advanced stage, terminal cases. At the symposium he was able to call the attention of the scientific community to NOE and how the extract had shown to be efficacious on cancer cases of different varieties. He was sure that his presentation would trigger serious and abundant research on NOE, and that it finally could be put into service for mankind.

The response from the scientific community was less than overwhelming. The skepticism centered mainly on the fact that the presentation contradicted what little literature there was on oleander species. Clearly the results presented could not be explained as an extension of prior art but Turkish scientists strongly denied the facts that Doctor Ozel had presented without any further research. To conclude, the medical community was reluctant to accept the results. Doctor Ozel was undaunted by the criticism and lack of support for the ideas presented. He continued his research and patients continued to seek treatment.

In 1974, he published additional case reports in the Turkish Medical Journal Dirim. Doctor Ozel resigned from his position as Chief Doctor at Mugla State Hospital that same year in order to be able to work on NOE and initiate research on the subject,

Doctor Ozel contacted various universities in Istanbul. Years passed and he realized that no serious scientific research could be performed in any of the local universities. In the meantime, his old patients referred new ones to him, and more cancer patients presented to him as word of the results of the treatment spread.

In 1985 he started to look for research facilities abroad. During 1986-1987 some tests performed in Europe proved the effect of NOE on the immune system as well as cancer tumors. The studies showed that it was at least six times as potent as the most active commercially available immune-stimulants (Schizophylan, Krestin and Lentinan, which were patented by the Japanese in the 1980s).

In 1988, a research team was formed at Munich University Pharmacology Institute to isolate the active components contained in the N.O. extract. Several polysaccharides were identified that might be responsible for some part of the immune activity. On 17-22 July 1990, the initial results were presented as a poster at the symposium of Biology and Chemistry of Active Natural Substances (BACANS) which was held in Bonn, Germany. The presentation was published in Planta Medica 1990-56:66. However, no single component of the extract was found to be the sole source of its benefits. Instead, the activity is induced by a complex mixture of components contained in the extract, acting synergistically to modulate the immune system. Since the early 1970s, Doctor Ozel has been treating patients with advanced and inoperable cancer as well as a wide variety of other of illnesses. His results have been truly remarkable. In fact, so fantastic were the stories of his success that Doctor Ozel had to endure long periods of controversy from the Turkish medical establishment and there were those who tried to charge the good doctor with being a charlatan. Happily, the truth of his successes won out and such charges were dropped from consideration when his results were proven. Scores of patients rose up to defend the good doctor, testifying about how they had been cured when all other treatment options had failed.

The patented name of Doctor Ozel's oleander extract is Anvirzel, whose trademark was once owned by Ozelle Pharmaceuticals, which was formed by Doctor Ozels son and other investors. Today, trademark rights are in dispute. Unfortunately, since Doctor Ozel had claimed that oleander was a cure for cancer, as opposed to a natural supplement, and since his extract was patented and given a trademark, the FDA now considers oleander as an unproven medicine which, because of the toxicity of the raw plant, must have it's safety and effectiveness proven before the FDA will allow it's use even as a herbal supplement, and so it is very difficult to obtain herbal supplements which contain oleander in the United States.

Today, the lengthy and costly three-phase FDA trial process for approval of Anvirzel or any other oleander extract, is far from over, although many people and millions of investor dollars are counting on it ultimately being approved. In 2000, Ozelle Pharmaceuticals had successful phase I FDA trials conducted on Anvirzel, but subsequently ran into investor problems and had to reorganize. Although Ozelle continues to publish plans that it will soon begin phase II trials with Anvirzel, such plans have not yet reached fruition and funding appears to continue to be a major problem for Ozelle.

In the interim, a competing company, Phoenix Biotech, also obtained a patent for Anvirzel in Honduras and has applied for a U.S. patent as well, and a clinic has been established in Honduras by the name of Salud Integral. For the past eight years, the clinic has successfully treated a number of patients, many of whom travel from the United States for initial diagnosis and treatment, as well as three-month supplies of Anvirzel for various cancers, hepatitis-C, psoriasis and other immune disorders.

Within just the past three years, a third competing company appeared by the name of Shimoda Atlantic Oncology Biosciences, and claimed to have developed its own oleander extract named Xenavex which it claimed was much stronger due to an ethanol extraction method. As it turned out, I and others exposed the company as a fraud that was created to cheat investors and the drug was actually a heart medication imported from Russia. Furthermore, although the imported Russian medicine does have slightly higher concentrations of oleandrin, the ethanol extraction method results in the loss of other compounds that researchers believe work together in a synergistic way to make oleander extract so powerful (over 500 trace compounds have been identified in an aqueous, or water, oleander extract, including vital long-chain polysaccharides that are lost in ethanol extraction methods because they precipitate out during the extraction process).

Sadly, I must report that it may be many years, if ever, before an oleander based medicine wins FDA approval. The simple fact is that it takes hundreds of millions of dollars to get a new drug successfully through all the FDA trials, and this pretty much bars competition to all but the very large pharmaceutical companies. Many feel that if the issue ever went to court, the patent itself would be hard to defend, since it is based on a common plant and a centuries-old folk remedy. Others feel that, because of the billions of dollars in profits at stake for the trillion-dollar world pharmaceutical industry and their myriad cancer treatments, no oleander medicine will ever be approved in the United States.

The best hope as of the time of this writing appears to be the development of an oleander based tablet by Phoenix Biotech which is reported to be have a much stronger concentration of oleandrin and the other cardiac glycosides while losing none of the other essential synergistic compounds. Only time will tell if a major pharmaceutical company with the requisite funds will pick up this new oleander product from Phoenix, shepherd it through FDA trials, and finally bring it to market.

Live Long, Live Healthy, Live Happy

Tony Isaacs, is a natural health researcher and author of books and articles about natural health including "Cancer's Natural Enemy" as well as song lyrics and humorous anecdotal stories. Mr. Isaacs also has The Best Years in Life website for baby boomers and others wishing to live longer, healthier and happier lives and he serves as a featured writer and consultant to the nationally famous Utopia Silver colloidal silver and natural supplement company. He is currently working on a major book project due for publication next year.